First multi-actor partnership tests chemical compounds for antibacterial activity
Antimicrobial resistance (AMR) is a global problem hindering treatment of bacterial infections, rendering many aspects of modern medicine less effective. AMR genes (ARGs) are frequently located on plasmids, which are self-replicating elements of DNA. They are often transmissible between bacteria, and some have spread globally. Novel strategies to combat AMR are needed, and plasmid curing and anti-plasmid approaches could reduce ARG prevalence, and sensitise bacteria to antibiotics.
Researchers at an Indian hospital have identified strains of hypervirulent, carbapenem-resistant Klebsiella pneumoniae associated with extremely high mortality rates, according to a new study in the Journal of the Association of Physicians of India.
The Indian government may be nearing a ban on the use of colistin for growth promotion in food-producing animals, according to media reports.
Monitoring and regulating irrigation water quality as well as developing affordable sanitation technologies is crucial, especially as the use of surface water and reclaimed wastewaters tends to become more and more common agricultural practice.
According to the Jim O’Neill Review on Antimicrobial Resistance, China uses around half the antibiotics consumed worldwide. Of these, 48% are consumed by humans and the rest is used in food-producing animals. The report suggests that AMR could cause a million premature deaths per year by 2050 in China alone.
This investigation showed the rapid emergence and high prevalence of MRMM in M. genitalium-infected patients in Cuba and confirmed the phenotypic resistance in isolates carrying MRMM.
UK livestock producers have been committed to – and successful in – meeting government targets on antibiotic usage over recent years, but Sweden is still leading the way.
New research underscores the need to dynamically optimize combination treatments based on the quantitative features of the bacterial response to the antibiotic or the β-lactamase inhibitor.
The Call on Diagnostics and Surveillance 2019 will fund joint transnational research projects addressing the development of diagnostic and surveillance tools, technologies and methods to detect antimicrobial resistance (AMR).
Two articles yesterday in Emerging Infectious Diseases describe severe infections caused by highly virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST) 398, a clonal type that is usually associated with animals.
The French government has released €40 million to help fund research into new antibiotics, as antibiotic resistance in France rises up the medical agenda.