An international collaboration has announced the results of the first scientific experiments at Europe’s new X-ray laser European XFEL. The pioneering work not only demonstrates that the new research facility can speed up experiments by more than an order of magnitude, it also reveals a previously unknown structure of an enzyme responsible for antibiotics resistance.
Monotherapy with meropenem–vaborbactam for Carbapenem-Resistant Enterobacteriaceae infection was associated with increased clinical cure, decreased mortality, and reduced nephrotoxicity compared with BAT.
The lack of new antibiotics is among the most critical challenges facing medicine. Researchers have been on the hunt for new drugs to combat “superbugs” that cannot be penetrated by current antibiotics.
Rather than looking for drugs that forcibly penetrate bacteria, researchers tried a new approach: tricking bacteria into taking up a molecule that looks like food, but wreaks havoc once inside. A study of this approach shows initial success in mice and humans.
With antibiotic-resistant “superbugs” now infecting 2 million people per year and a dearth of new medications in the pipeline to treat them, University of Colorado Boulder researchers are taking a novel approach to addressing the looming public health crisis: They’re helping develop new drugs to make old drugs work better.
Researchers found colistin-resistant bacteria in 49% vegetable, meat samples in Chennai. They have for the first time deciphered the mechanism by which food Klebsiella bacteria develop resistance to colisitin, a last-line antibiotic. Mutations and insertional inactivation of the mgrB gene, which is present in the chromosome, are responsible for colistin resistance in Klebsiella.