Regional Differences in Antibiotic-resistant Enterobacterales Urine Isolates in the United States: 2018-2020

Antimicrobial resistance (AMR) can complicate effective management of urinary tract infections (UTIs). We conducted a retrospective study of AMR in Enterobacterales urine isolates from ambulatory and hospitalized adult patients from 2018-2020 (BD Insights Research Database) to evaluate regional differences in isolates with an extended-spectrum beta-lactamase (ESBL)-producing phenotype or not susceptible to beta-lactams, fluoroquinolones (FQ), nitrofurantoin (NFT), trimethoprim/sulfamethoxazole (TMP/SMX), or multiple antibiotic classes (2+ or 3+). Our analyses included 349,741 Enterobacterales urine isolates from 321 inpatient facilities and 980,354 isolates from 338 ambulatory care facilities.