Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

  10 March 2022

Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy updated during treatment. The effects of such rapid antibiotic switching on the evolution of antibiotic resistance in individual patients are poorly understood. Here we find that low-frequency antibiotic resistance mutations emerge, contract, and even go to extinction within days of changes in therapy. 

Further reading: Nature Communications
Author(s): Hattie Chung et al
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