Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa
This study revealed a high burden of resistance against important antimicrobials such as streptomycin, neomycin, ceftriaxone, chloramphenicol, and tetracycline, including imipenem and meropenem. Genes encoding cephalosporin resistance are commonly situated on self-transmissible plasmids which may be promiscuous and capable of disseminating into a broad range of microbiota. Furthermore, the resistance of E. coli isolates to antibiotics of choice in human therapy such as aminoglycoside, chloramphenicol, carbapenem, and cephalosporin pose a grave danger for success in human chemotherapy. Resistance in nitrofurantoin, a drug not commonly in use in South Africa, suggests that factors other than selective pressure must have an impact on the emergence of resistant E. coli.
Boosting innovation to curb AMR?
AMR Innovation Mission UK 2021
The AMR Innovation Mission UK 2021 aims to add to the global curbing of AMR by boosting joint early & translational research, R&D, clinical development, validation, registration and commercialisation of vaccines, microbial diagnostics and antimicrobial products.