In line with other antibiotics, macrolide prescribing in primary care in England has decreased over the past 5 years, falling by 17.3% from 4.2 milllion items in 2015/2016 to 3.5 million items in 2019/2020. Macrolide resistance in Gram-positive infections is increasing, largely because of an increasing incidence of infections. Higher numbers of resistant infections are seen in older age groups.
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