Lessons Learned from First Ten Consecutive Cases of Intravenous Bacteriophage Therapy to Treat Multidrug Resistant Bacterial Infections at a Single Center in the US

Due to increasing multidrug resistant (MDR) infections there is an interest is assessing the use of bacteriophage therapy (BT) as an antibiotic alternative. After the first successful case of intravenous BT to treat a systemic MDR infection at our institution in 2017, the Center for Innovative Phage Applications and Therapeutics (IPATH) was created at the University of California, San Diego in June 2018.

We demonstrate the safety and feasibility of intravenous BT for a variety of infections and discuss practical considerations that will be critical for informing future clinical trials.