Investigation of Stress Response Genes in Antimicrobial Resistant Pathogens Sampled from Five Countries

Pathogens, which survive from stressed environmental conditions and evolve with antimicrobial resistance, cause millions of human diseases every year in the world. Fortunately, the NCBI Pathogen Detection Isolates Browser (NPDIB) collects the detected stress response genes and antimicrobial resistance genes in pathogen isolates sampled around the world. While several studies have been conducted to identify important antimicrobial resistance genes, little work has been done to analyze the stress response genes in the NPDIB database. In order to address this, this work conducted the first comprehensive statistical analysis of the stress response genes from five countries of the major residential continents, including the US, the UK, China, Australia, and South Africa.