High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
19 December 2020
Understanding the constraints that shape the evolution of antibiotic resistance is critical for predicting and controlling drug resistance. Despite its importance, however, a systematic investigation of evolutionary constraints is lacking. Here, we perform a high-throughput laboratory evolution of Escherichia coli under the addition of 95 antibacterial chemicals and quantified the transcriptome, resistance, and genomic profiles for the evolved strains.
Further reading: Nature Communications
Author(s): Tomoya Maeda, Junichiro Iwasawa, Hazuki Kotani, Natsue Sakata, Masako Kawada, Takaaki Horinouchi, Aki Sakai, Kumi Tanabe & Chikara Furusawa
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OUR UNDERWRITERS
Unrestricted financial support by:
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Antimicrobial Resistance Fighter Coalition |
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Evotec |
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JSS University |
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INTERNATIONAL FEDERATION PHARMACEUTICAL MANUFACTURERS & ASSOCIATIONS |
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