Genomic comparison of carbapenem-resistant Enterobacteriaceae from humans and gulls in Alaska

  12 March 2021

Wildlife may harbor clinically important antimicrobial resistant (AMR) bacteria, but the role of wildlife in the epidemiology of AMR bacterial infections in humans is largely unknown. In this study, we aimed to assess dissemination of theblaKPC carbapenemase gene among humans and gulls in Alaska.

Genomic analysis of CPE isolates suggested independent acquisition events among humans with no evidence for direct transmission ofblaKPC between people and gulls. However, some isolates shared conserved genetic elements surrounding blaKPC, suggesting possible exchange between species.

Our results highlight the genomic plasticity associated withblaKPC and demonstrate that sampling of wildlife may be useful for identifying clinically relevant antimicrobial resistance not observed through local passive surveillance in humans.

Author(s): Christina Ahlstrom, Anna Frick, Catherine Pongratz, Kimberly Spink, Catherine Xavier, Jonas Bonnedahl, and Andrew M. Ramey
Healthy Animals   Healthy Patients  
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