Collaboration to improve the quality of in vivo antibiotics testing

New antibiotics are crucial in the fight against antimicrobial resistance. Assessing the effectiveness of new antibiotics requires standardised high-quality infection models, readily available to stakeholders developing new antibacterial treatments. The Innovative Medicines Initiative project COMBINE is developing a standardised in vivo pneumonia model to test small molecule antibiotics. This model is now being evaluated through a unique collaboration with some of the main actors in the field: CARB-X & CAIRD, iiCON and Pharmacology Discovery Services.