Biocide-Induced Emergence of Antibiotic Resistance in Escherichia coli

  26 February 2021

Biocide use is essential and ubiquitous, exposing microbes to sub-inhibitory concentrations of antiseptics, disinfectants, and preservatives. This can lead to the emergence of biocide resistance, and more importantly, potential cross-resistance to antibiotics, although the degree, frequency, and mechanisms that give rise to this phenomenon are still unclear. Here, we systematically performed adaptive laboratory evolution of the gut bacteria Escherichia coli in the presence of sub-inhibitory, constant concentrations of ten widespread biocides. Our results show that 17 out of 40 evolved strains (43%) also decreased the susceptibility to medically relevant antibiotics.

Further reading: Frontiers inMicrobiology
Author(s): Beatriz Merchel Piovesan Pereira, Xiaokang Wang and Ilias Tagkopoulos
Clean Environment  


Unrestricted financial support by:

Antimicrobial Resistance Fighter Coalition


JSS University


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