Bacteriophage-Antibiotic Combinations: A Promising Alternative for Refractory Infections?

  18 March 2020

Phages used alone have potential advantages over antibiotics. These include high specificity to bacteria, which limits potential damage to the normal flora of the host; self-limiting action, meaning that phage numbers decline as the bacterial infection resolves; and phages’ adaptability with the bacterial host, in that they may infect previously phage-resistant bacterial mutants. However, recently published research has shown promising results with phage-antibiotic combinations against bacteria.

Author(s): TAYLOR MORRISETTE, PHARMD*+; RAZIEH KEBRIAEI, PHD+; SANDRA MORALES, PHD; AND MICHAEL J. RYBAK, PHARMD, MPH, PHD
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