An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

Antibiotic resistance is a global health crisis, especially for Gram-negative bacteria infections. NM102, a molecule, exhibits antimicrobial activity in infection contexts. It inhibits the Mutation Frequency Decline protein, sensitizing pathogenic bacteria to the host immune response and blocking infections. This could lead to the development of drugs to combat antimicrobial resistance.