A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

  28 January 2022

Detailed knowledge on how bacteria evade antibiotics and eventually develop resistance could open avenues for novel therapeutics and diagnostics. It is thereby key to develop a comprehensive genome-wide understanding of how bacteria process antibiotic stress, and how modulation of the involved processes affects their ability to overcome said stress. Here we undertake a comprehensive genetic analysis of how the major human pathogen Streptococcus pneumoniae responds to 20 antibiotics. We built a genome-wide atlas of drug susceptibility determinants and generate a genetic interaction network that connects cellular processes and genes of unknown function, which we show can be used as therapeutic targets.

Further reading: BioRxiv
Author(s): Dmitry Leshchiner, Federico Rosconi, Bharathi Sundaresh, Emily Rudmann, Luisa Maria Nieto Ramirez, Andrew T Nishimoto, Stephen Wood, Bimal Jana, Noemi Bujan, Kaiching Li, Jianmin Gao, Matthew Frank, Stephanie M Reeve, Richard E Lee, Charles O Rock, Jason W Rosch, View ORCID ProfileTim van Opijnen
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Unrestricted financial support by:

Antimicrobial Resistance Fighter Coalition

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