The Take 5 Campaign: Effects of an Intervention to Promote Five-Day Durations of Antibiotic Therapy for Common Infections in Urgent Care 

This quasi-experimental study evaluated the Take 5 campaign, an intervention promoting five-day antibiotic courses for common infections in urgent care. Conducted at two centers (2017–2023), it targeted skin infections, UTIs, sinusitis, otitis media, pneumonia, and COPD exacerbations. The campaign led to an immediate 10.7% rise in ≤5-day prescriptions and a continued monthly increase, raising adherence from 57.5% to 82.9%. Importantly, shorter durations did not increase subsequent antibiotic use or hospitalizations. Overall, the Take 5 intervention effectively reduced unnecessary antibiotic exposure without compromising patient outcomes.