Antibiotic potentiators as a promising strategy for combating antibiotic resistance

Antimicrobial resistance (AMR) poses a critical global health challenge. It arises from pathogens’ resistance to antibiotics due to misuse, overuse, and insufficient regulation. As new antibiotics emerge slowly, antibiotic potentiators can enhance existing treatments against resistant strains. Challenges such as toxicity and regulatory barriers necessitate further studies to optimize these agents. This review examines the mechanisms, sources, and recent advancements in antibiotic potentiation while highlighting its potential to combat AMR.