Using Genomics to Track Global Antimicrobial Resistance
The advancement in whole genome sequencing and the application of online tools for real-time detection of AMR determinants is essential for control and prevention strategies to combat the increasing threat of AMR.
The authors identified a number of accessible tools available in the prediction of AMR determinants to support expanding to establish global pathogen surveillance and AMR tracking based on genomics. In addition, they identified a number of preceding requirements for a successful transition such as curated AMR databases ensuring a high concordance between pheno- and genotypes, benchmarking designs, PT schemes, sharing options etc. There is however, a vital need for standardization of pipelines and databases as well as phenotypic predictions based on the genomic data.
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