Triple artemisinin-based combination therapies for malaria: a timely solution to counter antimalarial drug resistance

  15 March 2022

Drug resistance against antimalarials is inevitable, usually emerging slowly for approximately 20 years after they start being widely used, at which point there is a sudden onset of widespread resistance. 

This pattern has been seen for chloroquine, sulfadoxine-pyrimethamine, and most recently the components of artemisinin-based combination therapy (ACT), emphasising the need for a robust antimalarial drug pipeline featuring compounds with novel modes of action until global malaria eradication is achieved. While we await new compounds—seven of which are in translational and human exploratory studies but might fail at later stages of the pipeline —additional strategies are urgently needed to curb the persistent and rapid emergence of resistance to artemisinin-class and partner drugs.

Author(s): Ingrid Chen, Michelle S Hsiang
Effective Surveillance  


Unrestricted financial support by:

Antimicrobial Resistance Fighter Coalition


JSS University


Technology Database

Display your AMR Technology, Product and Service

Suppliers and Users of Technologies, Products and Services benefit from CAPI.
CAPI (Continuous AMR Partnering Initiative) unites Suppliers and Users worldwide with the aim to add to the curbing of AMR.

Read more and make your own Technology Page >>
What is going on with AMR?
Stay tuned with remarkable global AMR news and developments!