Sustaining Antimicrobial Stewardship in a High–Antibiotic Resistance Setting

 In this cohort study, after implementation of prospective review and feedback, the use trends increased for piperacillin-tazobactam and carbapenems and declined for other broad-spectrum antibiotics. After the addition of a computerized decision support system, the use trends decreased for piperacillin-tazobactam and carbapenems and for other broad-spectrum antibiotics.

These findings suggest that concurrent use of prospective review and feedback and a computerized decision support system may help to sustain the outcomes associated with antimicrobial stewardship programs.