Resistance patterns and virulence factors of Pseudomonas aeruginosa in hospitalized patients: A Saudi Arabian study

This study from King Khalid Hospital (Saudi Arabia) examined 817 cases of Pseudomonas aeruginosa infection to understand resistance patterns and related risk factors. Results showed that 73% of isolates were multidrug-resistant (MDR), with strongest resistance seen in hospital-acquired infections and patients using invasive devices such as ventilators, catheters, or central lines. Colistin, amikacin, and cefepime remained the most effective antibiotics, while ceftazidime showed the lowest activity. Biofilm formation was strongly linked to MDR strains, highlighting its role in persistent infections. The findings underscore the urgent need for stronger infection control, antimicrobial stewardship, and special attention to high-risk hospital patients to reduce the spread of MDR P. aeruginosa and improve treatment outcomes.