Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China

Since the gene encoding mobilized colistin resistance (mcr-1) was first reported in China in 2015, it has been reported in various Enterobacteriaceae worldwide. Escherichia coli, one of the main pathogens causing diarrhea, is the most prevalent, clinically identified species carrying mcr-1. This study aimed to investigate the epidemiologic and genomic characteristics of mcr-1 in E. coli from patients in Shanghai.

These data suggest that mcr-1 is prevalent in E. coli strains, especially those identified in diarrheal patients in Shanghai, and strengthening the surveillance of mcr-1 transmission, especially in children, is essential.