Antibiotic tolerance reduces the ability to prevent resistance under drug combination therapies

  13 January 2020

To improve patient outcomes as well as to reduce the potential for the emergence of resistance, it’s become common clinical practice to use combinations of antimicrobial drugs to treat the most serious and stubborn infections. Whereas antimicrobial resistance renders microbes invulnerable to the drugs designed to kill them, they can also become more tolerant of them, which is often associated with the failure of antibiotic treatments and the relapse of infections. Previous studies have demonstrated the rapid emergence of tolerance during single antibiotic treatments, which can subsequently promote the evolution of resistance. However, the effect of tolerance on the emergence of resistance when drug combinations are used remains unclear.

Source: EurekAlert
Author(s): EurekAlert
Effective Surveillance  
Back


Display your AMR technology / product:

Global AMR Technologies Database

  • Preventive – Diagnostic – Antimicrobial technologies
  • Academia – Research Institutes – Start ups – SMEs – Multinationals
  • Early research <-> near market (max 5)
  • Global reach for funding / co-development / licensing
Display your technology >>
What is going on with AMR?
Stay tuned with remarkable global AMR news and developments!