Prevalence Trends and Antimicrobial Resistance of Carbapenem-Resistant Gram-Negative Bacteria in Paediatric Patients in Sichuan Province: A Retrospective Study (2021-2025)

This large retrospective study (2021–2025) analyzed 2,523 carbapenem-resistant Gram-negative bacteria (CRGNB) isolates from hospitalized children in Sichuan Province, China. Infections were most common in infants under one year (41.8%), with Klebsiella pneumoniae and Acinetobacter baumannii as the predominant pathogens, and respiratory samples accounting for the majority of isolates. While resistance was widespread, some last-resort antibiotics—such as tigecycline, polymyxin B, and ceftazidime-avibactam—remained largely effective against key species. Overall, the study highlights a significant and region-specific burden of multidrug-resistant infections in pediatric populations, underscoring the urgent need for continued surveillance, targeted interventions, and optimized antimicrobial use in clinical practice.