Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008-2018

The study examined the epidemiology and impact of antimicrobial resistance (AMR) on cancer patients with bacteraemia at Oxford University Hospitals (OxUH) and Oslo University Hospital (OsUH) from 2008-2018. The study found that the highest resistance proportions were found for vancomycin-resistance in enterococci, carbapenem-resistance in Pseudomonas aeruginosa, and third-generation cephalosporin-resistance in Escherichia coli and Klebsiella pneumoniae. The observed mortality for all infections was 26.4% at OxUH, with an estimated counterfactual mortality without AMR of 24.7%. The PAF was 6.3%, indicating an estimated 32 of 509 deaths could be attributed to AMR.