Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: An inter-laboratory study

  07 October 2019

The authors found that participating laboratories produced discordant predictions from identical WGS data. These deficits, at the final analytical stage of using WGS to predict AMR, suggest caution when using this technology in clinical settings. Comprehensive public resistance sequence databases and standardisation in the comparisons between genotype and resistance phenotypes will be fundamental before AST prediction using WGS can be successfully implemented in clinical microbiology laboratories.

Source: bioRxiv
Authors: Ronan M. Doyle, Denise M. O’Sullivan, Sean D. Alle, Sebastian Bruchmann, Taane Clark, Andreu Coello Pelegrin, Martin Cormican, Ernest Diez Benavente, Matthew J. Ellington, Elaine McGrath, Yair Motro, Thi Phuong Thuy Nguyen, Jody Phela, Liam P. Shaw, Richard A. Stabler, Alex van Belkum, Lucy van Dorp, Neil Woodford, Jacob Moran-Gilad, Jim F. Huggett, Kathryn A. Harris
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