Novel antibiotics effective against gram-positive and -negative multi-resistant bacteria with limited resistance

  22 July 2019

The authors generated a new family of peptidomimetics—cyclic heptapseudopeptides—inspired from a natural bacterial peptide. Out of the 4 peptides studied, 2 are effective against methicillin-resistant Staphylococcus aureus (MRSA) in mild and severe sepsis mouse models without exhibiting toxicity on human erythrocytes and kidney cells, zebrafish embryos, and mice. These new compounds are safe at their active doses and above, without nephrotoxicity. Efficacy was also demonstrated against Pseudomonas aeruginosa and MRSA in a mouse skin infection model. Importantly, these compounds did not result in resistance after serial passages for 2 weeks and 4 or 6 days’ exposure in mice.

Source: PLOS Biology
Authors: Irène Nicolas, Valérie Bordeau, Arnaud Bondon, Michèle Baudy-Floc’h, Brice Felden
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Emerging Antimicrobials and Diagnostics in AMR 2019

International Matchmaking Symposium on 19-20 November, 2019 in Amsterdam, The Netherlands.

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